Polycystic Ovary Syndrome (PCOS) and Functional Hypothalamic Amenorrhea (FHA): reproductive and metabolic health
This research line focuses on the complex interplay between hormonal imbalances and metabolic health in women suffering from PCOS or FHA.
- Current research:
- Evaluation of reproductive parameters and cardiometabolic risks in women with PCOS and FHA from adolescence to adulthood.
- Clinical effects of integrative and pharmacological therapies on gynecological-endocrine disorders.
- Optimization of protocols for office ovulation induction in endocrine infertility.
- Comparative analysis of the endocrine signatures and recovery patterns in patients with Functional Hypothalamic Amenorrhea (FHA).
- Laboratory expertise:
- Advanced ultrasound characterization of ovarian morphology.
- Basal and dynamic assessment of insulin resistance through Oral Glucose Tolerance Test (OGTT).
- Hormonal profiling and dynamic endocrine testing.
Adolescent Gynecology and Personalized Contraception
This line explores the unique endocrine needs of adolescents and the development of tailored contraceptive strategies for patients with underlying medical conditions.
- Current research:
- Management of menstrual irregularities and dysmenorrhea.
- Study of pubertal induction protocols for patients with delayed puberty or hypergonadotropic hypogonadism.
- Evaluation of personalized contraceptive counseling for women with comorbidities.
- Impact of hormonal contraceptives on bone mass accrual.
- Laboratory expertise:
- Pelvic ultrasound for the assessment of Müllerian structures and pubertal staging.
- Body composition analysis via DEXA to monitor the metabolic impact of hormonal therapies in young patients.
- Implementation of clinical guidelines for the safe prescription of contraceptives.
- Hormonal profiling and monitoring of the hypothalamic-pituitary-ovarian axis during pubertal development.
Menopause and Healthy Aging
This line focuses on the physiological transition to menopause and the long-term management of post-menopausal health.
- Current research:
- Evaluation of the efficacy and safety profiles of Hormone Replacement Therapy (HRT) formulations.
- Impact of the menopausal transition on cardiovascular health and metabolic markers.
- Study of bone mineral density and the prevention of osteoporosis through hormonal intervention.
- Assessment of quality of life and symptomatic relief in patients with severe climateric symptoms.
- Laboratory expertise:
- Management of clinical trials focused on menopausal health and healthy aging.
- Monitoring of biochemical markers of bone turnover and metabolic health.
- Monitoring of Bone Mineral Density (BMD) and body composition via Dual-Energy X-ray Absorptiometry (DEXA).
- Integrated clinical-ultrasound assessment of the urogenital system in post-menopause.
Premature Ovarian Insufficiency (POI)
This research line focuses on the etiology and long-term health management of women experiencing premature loss of ovarian function before the age of 40.
- Current research:
- Investigation into the genetic, autoimmune, and environmental determinants of Primary Ovarian Insufficiency (POI).
- Optimization of Hormone Replacement Therapy (HRT) protocols to mimic physiological estrogen exposure in young patients.
- Evaluation of long-term bone health and cardiovascular risks associated with early-onset hypoestrogenism.
- Study of emotional well-being and fertility preservation options in the context of early ovarian aging.
- Laboratory expertise:
- Longitudinal monitoring of the ovarian reserve using Anti-Müllerian Hormone (AMH) and Antral Follicle Count (AFC).
- Quantitative assessment of Bone Mineral Density (BMD) via Dual-Energy X-ray Absorptiometry (DEXA) to monitor osteoporosis risk.
- Advanced dynamic endocrine testing to differentiate between various types of hypergonadotropic amenorrhea.
- Specialized clinical management of premature menopause within a multidisciplinary framework.